George finished with 18 points and George Hill added 15 for Indiana. Hill started and played 33 minutes despite a sore right groin.
West liked the Pacers' chances before the game with Smith, Harris and Morrow unable to play. It just didn't work out the way he had hoped.
"Even though we had it close, they controlled the game from start to finish," West said. "They were locked in offensively. We just couldn't put up a big enough fight to slow them down."
Kyle Korver scored five points in a single possession late in the third to push the lead to 12 points.
After officials watched a video replay, the call was upheld that Lance Stephenson committed a flagrant foul on Korver, pushing him to the floor on a play away from the ball. Korver hit both free throws and then a 3-pointer at the 4:10 mark to make it 77-65.
"He purposely ran at me," Korver said. "I saw him coming. I knew he was going to hit me like that. I just took it, you know? But he put a shoulder into my chest."
The Hawks' lead swelled to 18 with 2:12 remaining in the third on Johnson's putback.
Horford, who played 37 minutes despite a right hip contusion, hit a 17-footer to make it 93-88 with 5:02 remaining.
Indiana never led after Korver's 3-pointer made it 18-16 at the 4:13 mark of the first.
NOTES: Smith was injured in Friday's win at Cleveland. Drew listed his status as day to day. ... Stephenson was helped off the floor with 5:44 remaining after getting hit on the left side of the face. ... Atlanta has won 11 straight at home over Indiana and four straight overall. ... Harris missed his six straight games with a sore left foot. ... Morrow is recovering from a strained right hip after getting hurt at Cleveland. ... Pacers reserve G Sam Young did not travel with the team because of the flu. ... Atlanta is 4-0 with Williams in the starting lineup.